尽管条件变异自动编码器（CVAE）模型比传统的SEQ2SEQ模型可以产生更多的多样化响应，但响应通常与输入词的相关性低或与问题不合逻辑。进行因果分析以研究背后的原因，并提供了一种寻找调解人并减轻对话中混杂偏见的方法。具体而言，我们建议预测调解人，以保留相关信息，并自动将调解人纳入生成过程中。此外，动态主题图指导条件变异自动编码器（TGG-CVAE）模型用于补充语义空间并减少响应中的混杂偏置。广泛的实验表明，所提出的模型能够产生相关和信息性的响应，并且在自动指标和人类评估方面优于最先进的响应。

营销活动是一系列战略活动，可以促进企业的目标。在真正的工业场景中，营销活动的效果预测非常复杂且具有挑战性，因为通常从观察数据中学到了先验知识，而没有任何营销活动干预。此外，每个主题始终在几个营销活动的干预下同时受到干扰。因此，我们无法轻松解析和评估单个营销活动的效果。据我们所知，目前尚无有效的方法来解决此类问题，即，基于具有多个相互缠绕事件的层次结构对个体级别的预测任务进行建模。在本文中，我们对效果预测任务中涉及的基础解析树的结构进行了深入的分析，并进一步建立了一个层次结构胶囊预测网络（HAPNET）来预测营销活动的影响。基于合成数据和实际数据的广泛结果证明了我们模型比最新方法的优越性，并在实际工业应用中表现出显着的实用性。

An unbiased scene graph generation (SGG) algorithm referred to as Skew Class-balanced Re-weighting (SCR) is proposed for considering the unbiased predicate prediction caused by the long-tailed distribution. The prior works focus mainly on alleviating the deteriorating performances of the minority predicate predictions, showing drastic dropping recall scores, i.e., losing the majority predicate performances. It has not yet correctly analyzed the trade-off between majority and minority predicate performances in the limited SGG datasets. In this paper, to alleviate the issue, the Skew Class-balanced Re-weighting (SCR) loss function is considered for the unbiased SGG models. Leveraged by the skewness of biased predicate predictions, the SCR estimates the target predicate weight coefficient and then re-weights more to the biased predicates for better trading-off between the majority predicates and the minority ones. Extensive experiments conducted on the standard Visual Genome dataset and Open Image V4 \& V6 show the performances and generality of the SCR with the traditional SGG models.

In the field of cross-modal retrieval, single encoder models tend to perform better than dual encoder models, but they suffer from high latency and low throughput. In this paper, we present a dual encoder model called BagFormer that utilizes a cross modal interaction mechanism to improve recall performance without sacrificing latency and throughput. BagFormer achieves this through the use of bag-wise interactions, which allow for the transformation of text to a more appropriate granularity and the incorporation of entity knowledge into the model. Our experiments demonstrate that BagFormer is able to achieve results comparable to state-of-the-art single encoder models in cross-modal retrieval tasks, while also offering efficient training and inference with 20.72 times lower latency and 25.74 times higher throughput.

Deep learning has been widely used for protein engineering. However, it is limited by the lack of sufficient experimental data to train an accurate model for predicting the functional fitness of high-order mutants. Here, we develop SESNet, a supervised deep-learning model to predict the fitness for protein mutants by leveraging both sequence and structure information, and exploiting attention mechanism. Our model integrates local evolutionary context from homologous sequences, the global evolutionary context encoding rich semantic from the universal protein sequence space and the structure information accounting for the microenvironment around each residue in a protein. We show that SESNet outperforms state-of-the-art models for predicting the sequence-function relationship on 26 deep mutational scanning datasets. More importantly, we propose a data augmentation strategy by leveraging the data from unsupervised models to pre-train our model. After that, our model can achieve strikingly high accuracy in prediction of the fitness of protein mutants, especially for the higher order variants (> 4 mutation sites), when finetuned by using only a small number of experimental mutation data (<50). The strategy proposed is of great practical value as the required experimental effort, i.e., producing a few tens of experimental mutation data on a given protein, is generally affordable by an ordinary biochemical group and can be applied on almost any protein.

Three-dimensional (3D) ultrasound imaging technique has been applied for scoliosis assessment, but current assessment method only uses coronal projection image and cannot illustrate the 3D deformity and vertebra rotation. The vertebra detection is essential to reveal 3D spine information, but the detection task is challenging due to complex data and limited annotations. We propose VertMatch, a two-step framework to detect vertebral structures in 3D ultrasound volume by utilizing unlabeled data in semi-supervised manner. The first step is to detect the possible positions of structures on transverse slice globally, and then the local patches are cropped based on detected positions. The second step is to distinguish whether the patches contain real vertebral structures and screen the predicted positions from the first step. VertMatch develops three novel components for semi-supervised learning: for position detection in the first step, (1) anatomical prior is used to screen pseudo labels generated from confidence threshold method; (2) multi-slice consistency is used to utilize more unlabeled data by inputting multiple adjacent slices; (3) for patch identification in the second step, the categories are rebalanced in each batch to solve imbalance problem. Experimental results demonstrate that VertMatch can detect vertebra accurately in ultrasound volume and outperforms state-of-the-art methods. VertMatch is also validated in clinical application on forty ultrasound scans, and it can be a promising approach for 3D assessment of scoliosis.

Image captioning is one of the straightforward tasks that can take advantage of large-scale web-crawled data which provides rich knowledge about the visual world for a captioning model. However, since web-crawled data contains image-text pairs that are aligned at different levels, the inherent noises (e.g., misaligned pairs) make it difficult to learn a precise captioning model. While the filtering strategy can effectively remove noisy data, however, it leads to a decrease in learnable knowledge and sometimes brings about a new problem of data deficiency. To take the best of both worlds, we propose a noise-aware learning framework, which learns rich knowledge from the whole web-crawled data while being less affected by the noises. This is achieved by the proposed quality controllable model, which is learned using alignment levels of the image-text pairs as an additional control signal during training. The alignment-conditioned training allows the model to generate high-quality captions of well-aligned by simply setting the control signal to desired alignment level at inference time. Through in-depth analysis, we show that our controllable captioning model is effective in handling noise. In addition, with two tasks of zero-shot captioning and text-to-image retrieval using generated captions (i.e., self-retrieval), we also demonstrate our model can produce high-quality captions in terms of descriptiveness and distinctiveness. Code is available at \url{https://github.com/kakaobrain/noc}.

Automatic image colorization is a particularly challenging problem. Due to the high illness of the problem and multi-modal uncertainty, directly training a deep neural network usually leads to incorrect semantic colors and low color richness. Existing transformer-based methods can deliver better results but highly depend on hand-crafted dataset-level empirical distribution priors. In this work, we propose DDColor, a new end-to-end method with dual decoders, for image colorization. More specifically, we design a multi-scale image decoder and a transformer-based color decoder. The former manages to restore the spatial resolution of the image, while the latter establishes the correlation between semantic representations and color queries via cross-attention. The two decoders incorporate to learn semantic-aware color embedding by leveraging the multi-scale visual features. With the help of these two decoders, our method succeeds in producing semantically consistent and visually plausible colorization results without any additional priors. In addition, a simple but effective colorfulness loss is introduced to further improve the color richness of generated results. Our extensive experiments demonstrate that the proposed DDColor achieves significantly superior performance to existing state-of-the-art works both quantitatively and qualitatively. Codes will be made publicly available.

Obtaining ground truth data in medical imaging has difficulties due to the fact that it requires a lot of annotating time from the experts in the field. Also, when trained with supervised learning, it detects only the cases included in the labels. In real practice, we want to also open to other possibilities than the named cases while examining the medical images. As a solution, the need for anomaly detection that can detect and localize abnormalities by learning the normal characteristics using only normal images is emerging. With medical image data, we can design either 2D or 3D networks of self-supervised learning for anomaly detection task. Although 3D networks, which learns 3D structures of the human body, show good performance in 3D medical image anomaly detection, they cannot be stacked in deeper layers due to memory problems. While 2D networks have advantage in feature detection, they lack 3D context information. In this paper, we develop a method for combining the strength of the 3D network and the strength of the 2D network through joint embedding. We also propose the pretask of self-supervised learning to make it possible for the networks to learn efficiently. Through the experiments, we show that the proposed method achieves better performance in both classification and segmentation tasks compared to the SoTA method.

Steering language generation towards objectives or away from undesired content has been a long-standing goal in utilizing language models (LM). Recent work has demonstrated reinforcement learning and weighted decoding as effective approaches to achieve a higher level of language control and quality with pros and cons. In this work, we propose a novel critic decoding method for controlled language generation (CriticControl) that combines the strengths of reinforcement learning and weighted decoding. Specifically, we adopt the actor-critic framework to train an LM-steering critic from non-differentiable reward models. And similar to weighted decoding, our method freezes the language model and manipulates the output token distribution using called critic, improving training efficiency and stability. Evaluation of our method on three controlled generation tasks, namely topic control, sentiment control, and detoxification, shows that our approach generates more coherent and well-controlled texts than previous methods. In addition, CriticControl demonstrates superior generalization ability in zero-shot settings. Human evaluation studies also corroborate our findings.